IMMUNE-PD1

Wnt signaling inhibition, immune-activating peptides, vitamins, minerals, and PD-1 inhibitors each help combat cancer by disrupting cancer cell survival mechanisms, enhancing immune responses against tumors, and reactivating immune detection to effectively target and destroy cancer cells.

Welcome to IMMUNE-PD1: Harnessing the Immune System to Fight Cancer

Product Name: IMMUNE-PD1

IMMUNE-PD1 is a cutting-edge, small-molecule inhibitor that targets the PD-1/PD-L1 immune checkpoint pathway—a crucial escape route used by many cancers. Designed as a powerful cancer immunotherapy tool, IMMUNE-PD1 is formulated to enable the immune system to detect and combat cancer cells.

Mechanism of Action

IMMUNE-PD1 works by inducing dimerization and sequestration of PD-L1, effectively inhibiting the PD-1/PD-L1 interaction. This disruption prevents cancer cells from evading immune detection, allowing the body’s immune system to recognize and destroy them. IMMUNE-PD1’s unique mechanism provides an innovative approach compared to large antibody therapies like Pembrolizumab and Nivolumab, overcoming key limitations such as bioavailability, cost, and side effects.

Wnt Signaling Inhibition: Disrupts cancer stem cell pathways, reducing tumor growth in cancers like breast, colon, and prostate cancer.

Unchecked Wnt Signaling has the following effects:

Energy Disruption: Targets mitochondrial function and disrupts oxidative phosphorylation in cancer cells, especially useful in hypoxic tumor environments.

Vitamin D3: Known to support immune regulation, enhancing T-cell function. The mechanisms through which vitamin D3 exerts these effects are varied:

  • Inducing Apoptosis: Vitamin D3 promotes apoptosis in cancer cells, reducing their ability to survive and multiply uncontrollably.
  • Inhibiting Cell Proliferation: It restricts the rapid division and replication of cancer cells, helping to prevent tumor growth.
  • Reducing Inflammation: By modulating immune responses and reducing inflammation, vitamin D3 limits the environment that can foster cancer growth.
  • Enhancing Immune Function: Vitamin D3 strengthens immune activity, aiding in the detection and destruction of abnormal cells before they become fully malignant.
  • Blocking Angiogenesis: It helps prevent the formation of new blood vessels that would otherwise supply tumors with nutrients, slowing tumor progression.

Selenium’s Anti-Cancer Mechanisms: Each day, cells in your body undergo thousands of potentially cancerous changes. Rather than preventing this completely, an effective approach to cancer prevention focuses on strengthening the body’s natural defenses to eliminate these abnormal cells as early as possible, stopping them from developing into malignant tumors.

Selenium offers multiple, complementary pathways to prevent cancer development—a property known as pleiotropy. This means selenium can target cancer cells on many fronts and at various stages of their development. Such versatility is crucial, as cancers have multiple causes and mechanisms that often evade single-target treatments.

Research has identified 12 specific mechanisms by which selenium helps prevent potentially cancerous cells from progressing into full-blown tumors:

  • Regulating lipoxygenases, enzymes that create inflammatory molecules supporting cancer growth.
  • Directly reducing oxidative stress, which leads to damaging free radicals.
  • Protecting selenoproteins that are vital for antioxidant recycling.
  • Detoxifying cancer-causing metals.
  • Activating “phase II” liver enzymes that neutralize organic carcinogens.
  • Inhibiting DNA changes that precede cancerous transformations.
  • Deactivating transcription factors needed by cancer cells to sustain growth.
  • Disrupting the cell replication cycle that cancer cells rely on for rapid growth.
  • Inducing apoptosis, the programmed cell death that’s impaired in cancer cells, allowing their unchecked reproduction.
  • Boosting immune activity to detect and destroy emerging cancer cells.
  • Downregulating sex hormone receptors that certain cancers use to grow.
  • Reducing tumor invasion and metastasis.

Together, these mechanisms amplify selenium’s protective effect against cancer, not all forms of selenium produce the same benefits; different forms of selenium can vary in their effectiveness.

Immune Activating Peptides: Mimic carbohydrates and bind to specific receptors on the cell surface to trigger an anti-tumor response. Enhance dendritic and T-cell activation, fostering robust immune responses against cancer cells.

α-Tocopheryl Succinate Selective Cancer Cell Targeting: α-Tocopheryl succinate, a vitamin E analogue with pro-apoptotic properties, selectively targets and kills cells with malignant or transformed characteristics, such as various hematopoietic and carcinoma cell lines, while remaining non-toxic to normal, healthy cells. The potential of this micronutrient for cancer therapy and/or prevention, offering a promising approach with minimal side effects.

Here are the key mechanisms through which it combats cancer:

  • Induction of Apoptosis: α-Tocopheryl succinate triggers programmed cell death specifically in cancer cells. This happens through mitochondrial pathways, leading to a loss of mitochondrial membrane potential, which is essential for cancer cell survival.
  • Inhibition of Cell Proliferation: By disrupting the cell cycle, α-tocopheryl succinate can halt cancer cell division, slowing tumor growth and preventing further malignant spread.
  • Oxidative Stress Regulation: α-Tocopheryl succinate increases oxidative stress selectively in cancer cells, resulting in cellular damage that leads to their death. This effect spares normal cells, which can better manage and neutralize oxidative stress.
  • Anti-Angiogenesis Effects: It hinders the formation of new blood vessels (angiogenesis) that tumors need for sustained growth and nutrient supply, effectively starving the tumor.
  • Modulation of Immune Response: α-Tocopheryl succinate can enhance immune system activity, making cancer cells more susceptible to immune attack and supporting the body’s own defenses in eliminating these cells.

Clinical Benefits of IMMUNE-PD1

  • Immune Checkpoint Inhibition: IMMUNE-PD1 offers a novel therapeutic approach with advantages over traditional antibody therapies, including better bioavailability, lower costs, and reduced adverse reactions.
  • Versatile Cancer Immunotherapy: IMMUNE-PD1 blocks the PD-1/PD-L1 interaction, showing promise across a wide range of cancers that express PD-L1, including melanoma, non-small-cell lung cancer, Hodgkin’s lymphoma, and more.

Pharmacokinetics and Key Advantages

  • Enhanced Tissue Penetration: IMMUNE-PD1’s small molecular size allows improved tissue penetration, which can lead to more effective tumor infiltration compared to large monoclonal antibodies.
  • Improved Pharmacokinetics: With an IC50 of ~29.00 µM, IMMUNE-PD1 is optimized for efficiency, and its oral bioavailability provides an easy-to-administer, non-invasive option for patients.
  • Reduced Immune Reactions: IMMUNE-PD1’s formulation minimizes the risk of immune-related side effects often seen with antibody-based therapies.

Product Formulation and Usage

For Transdermal Application Only

  • Container: 5ml with an airless pump
  • Appearance: Red cream, which may cause temporary skin staining
  • Approximate Dosage: 64 pumps per 5ml container

Recommended Application:

  1. Wash and dry hands and forearm or wrist.
  2. Apply the cream to the inside of the forearm or wrist.
  3. Rub in thoroughly until fully absorbed.

Dosage Guidelines:

  • Daily Dose: Apply one to four pumps once or twice daily.
  • Higher Dosage: Acceptable as needed based on clinical advice.

Ingredients

Transdermal Gel Base: Water, isopropyl palmitate, lecithin, carbomer, ethanol, potassium chloride, amino-2-methyl-2-propanol-1, vitamin E acetate, D-alpha tocopheryl succinate.

Active Components (per pump):

  • Immune Activating Peptide: 0.02mg
  • Vitamin D3: 5,000 IU
  • PD-1/PD-L1 Inhibitor: 2.56mg
  • Wnt Signaling Inhibitor: 1.00mg
  • Selenium as
    • Se-Methyl L-Selenocysteine
    • L-selenomethionine (yeast free)
    • Sodium selenite
  • D-alpha tocopheryl succinate 300 mcg

Storage and Handling

  • Storage Conditions: Store away from direct light and heat.
  • Long-Term Storage: Refrigeration is recommended for optimal stability.

Potential Side Effects

  • Skin Staining: Temporary red staining of the application area.
  • Possible Skin Irritation: Mild irritation may occur at the application site.

IMMUNE-PD1 offers a unique, effective way to inhibit the PD-1/PD-L1 checkpoint, unleashing the power of the immune system to target and eliminate cancer cells. With its innovative approach, IMMUNE-PD1 provides a promising solution for cancers that overexpress PD-L1, bringing renewed hope to patients and practitioners in the fight against cancer.

 PD-1/PD-L1

Immunotherapies based on anti-PD-1/PD-L1 pathway antibodies. (A) Inhibition of T cell activity caused by binding programmed death ligand 1 (PD-L1) to programmed death (PD-1). (B) Activization of T cell activity by using anti-PD-1 or anti-PD-L1 antibodies. The cancer cells become immunogenic again. This leads to recognition of tumor cells by T cells and final elimination by the host immune system.